How ATP-Competitive Inhibitors Allosterically Modulate Tyrosine Kinases That Contain a Src-like Regulatory Architecture

Small molecule kinase inhibitors that stabilize distinct ATP binding site conformations can differentially modulate the global conformation of Src-family kinases (SFKs). However, it is unclear which specific ATP binding site contacts are responsible for modulating the global conformation of SFKs and...

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Bibliografiset tiedot
Julkaisussa:ACS Chem Biol
Päätekijät: Fang, Linglan, Vilas-Boas, Jessica, Chakraborty, Sujata, Potter, Zachary E., Register, Ames C., Seeliger, Markus A., Maly, Dustin J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7700871/
https://ncbi.nlm.nih.gov/pubmed/32479050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00429
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