A carregar...

Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands

The accumulation of unfolded proteins under endoplasmic reticulum (ER) stress leads to the activation of the multi-domain protein sensor IRE1α as part of the unfolded protein response (UPR). Clustering of IRE1α lumenal domains in the presence of unfolded proteins promotes kinase trans-autophosphoryl...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Feldman, Hannah C., Tong, Michael, Wang, Likun, Meza-Acevedo, Rosa, Gobillot, Theodore A., Lebedev, Ivan, Gliedt, Micah J., Hari, Sanjay B., Mitra, Arinjay K., Backes, Bradley J., Papa, Feroz R., Seeliger, Markus A., Maly, Dustin J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992410/
https://ncbi.nlm.nih.gov/pubmed/27227314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00940
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!