Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival

Master regulators of the unfolded protein response (UPR), IRE1alpha and PERK promote adaptation or apoptosis depending on the level of endoplasmic reticulum (ER) stress. While the UPR is activated in many cancers, its effects on tumor growth remain unclear. Derived from endocrine cells, pancreatic n...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Moore, Paul C., Qi, Jenny Y., Thamsen, Maike, Ghosh, Rajarshi, Peng, Justin, Gliedt, Micah J., Meza-Acevedo, Rosa, Warren, Rachel E., Hiniker, Annie, Kim, Grace E., Maly, Dustin J., Backes, Bradley J., Papa, Feroz R., Oakes, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911642/
https://ncbi.nlm.nih.gov/pubmed/31672843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1116
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