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Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress
Depending on endoplasmic reticulum (ER) stress levels, the ER transmembrane multi-domain protein IRE1α promotes either adaptation or apoptosis. Unfolded ER proteins cause IRE1α lumenal domain homo-oligomerization, inducing trans auto-phosphorylation that further drives homo-oligomerization of its cy...
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Publicado no: | Cell |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4244221/ https://ncbi.nlm.nih.gov/pubmed/25018104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.07.002 |
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