IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death during endoplasmic reticulum stress

When unfolded proteins accumulate to irremediably high levels within the endoplasmic reticulum (ER), intracellular signaling pathways called the unfolded protein response (UPR) become hyperactivated to cause programmed cell death. We discovered that thioredoxin-interacting protein (TXNIP) is a criti...

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Detalhes bibliográficos
Main Authors: Lerner, Alana G., Upton, John-Paul, Praveen, P.V.K., Ghosh, Rajarshi, Nakagawa, Yoshimi, Igbaria, Aeid, Shen, Sarah, Nguyen, Vinh, Backes, Bradley J., Heiman, Myriam, Heintz, Nathaniel, Greengard, Paul, Hui, Simon, Tang, Qizhi, Trusina, Ala, Oakes, Scott A., Papa, Feroz R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014071/
https://ncbi.nlm.nih.gov/pubmed/22883233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.07.007
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