IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death during endoplasmic reticulum stress

When unfolded proteins accumulate to irremediably high levels within the endoplasmic reticulum (ER), intracellular signaling pathways called the unfolded protein response (UPR) become hyperactivated to cause programmed cell death. We discovered that thioredoxin-interacting protein (TXNIP) is a criti...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Lerner, Alana G., Upton, John-Paul, Praveen, P.V.K., Ghosh, Rajarshi, Nakagawa, Yoshimi, Igbaria, Aeid, Shen, Sarah, Nguyen, Vinh, Backes, Bradley J., Heiman, Myriam, Heintz, Nathaniel, Greengard, Paul, Hui, Simon, Tang, Qizhi, Trusina, Ala, Oakes, Scott A., Papa, Feroz R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014071/
https://ncbi.nlm.nih.gov/pubmed/22883233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.07.007
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge