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Bivalent inhibitors of the tyrosine kinases ABL and SRC: Determinants of potency and selectivity
We recently reported a chemical genetic method for generating bivalent inhibitors of protein kinases. This method relies on the use of the DNA repair enzyme O(6)-alkylguanine-DNA alkyltransferase (AGT) to display an ATP-competitive inhibitor and a ligand that targets a secondary binding domain. With...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3268058/ https://ncbi.nlm.nih.gov/pubmed/21060940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0mb00108b |
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