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Targeting Diverse Signaling Interaction Sites Allows the Rapid Generation of Bivalent Kinase Inhibitors
The identification of potent and selective modulators of protein kinase function remains a challenge and new strategies are needed for generating these useful ligands. Here, we describe the generation of bivalent inhibitors of three unrelated protein kinases: the CAMK family kinase Pim1, the mitogen...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3306478/ https://ncbi.nlm.nih.gov/pubmed/22148755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200387g |
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