Integrative Tumor and Immune Cell Multi-omic Analyses Predict Response to Immune Checkpoint Blockade in Melanoma

In this study, we incorporate analyses of genome-wide sequence and structural alterations with pre- and on-therapy transcriptomic and T cell repertoire features in immunotherapy-naive melanoma patients treated with immune checkpoint blockade. Although tumor mutation burden is associated with improve...

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Publicado en:Cell Rep Med
Main Authors: Anagnostou, Valsamo, Bruhm, Daniel C., Niknafs, Noushin, White, James R., Shao, Xiaoshan M., Sidhom, John William, Stein, Julie, Tsai, Hua-Ling, Wang, Hao, Belcaid, Zineb, Murray, Joseph, Balan, Archana, Ferreira, Leonardo, Ross-Macdonald, Petra, Wind-Rotolo, Megan, Baras, Alexander S., Taube, Janis, Karchin, Rachel, Scharpf, Robert B., Grasso, Catherine, Ribas, Antoni, Pardoll, Drew M., Topalian, Suzanne L., Velculescu, Victor E.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691441/
https://ncbi.nlm.nih.gov/pubmed/33294860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2020.100139
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