Dynamics of tumor and immune responses during immune checkpoint blockade in non-small cell lung cancer

Despite the initial successes of immunotherapy, there is an urgent clinical need for molecular assays that identify patients more likely to respond. Here we report that ultrasensitive measures of circulating tumor DNA (ctDNA) and T cell expansion can be used to assess responses to immune checkpoint...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Anagnostou, Valsamo, Forde, Patrick M., White, James R., Niknafs, Noushin, Hruban, Carolyn, Naidoo, Jarushka, Marrone, Kristen, Sivakumar, I.K. Ashok, Bruhm, Daniel C., Rosner, Samuel, Phallen, Jillian, Leal, Alessandro, Adleff, Vilmos, Smith, Kellie N., Cottrell, Tricia R., Rhymee, Lamia, Palsgrove, Doreen N., Hann, Christine L., Levy, Benjamin, Feliciano, Josephine, Georgiades, Christos, Verde, Franco, Illei, Peter, Li, Qing Kay, Gabrielson, Edward, Brock, Malcolm V., Isbell, James M., Sauter, Jennifer L., Taube, Janis, Scharpf, Robert B., Karchin, Rachel, Pardoll, Drew M., Chaft, Jamie E., Hellmann, Matthew D., Brahmer, Julie R., Velculescu, Victor E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6432636/
https://ncbi.nlm.nih.gov/pubmed/30541742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-1127
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