Multimodal genomic features predict outcome of immune checkpoint blockade in non-small-cell lung cancer

Despite progress in immunotherapy, identifying patients that respond has remained a challenge. Through analysis of whole-exome and targeted sequence data from 5,449 tumors, we found a significant correlation between tumor mutation burden (TMB) and tumor purity, suggesting that low tumor purity tumor...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Cancer
Main Authors: Anagnostou, Valsamo, Niknafs, Noushin, Marrone, Kristen, Bruhm, Daniel C., White, James R., Naidoo, Jarushka, Hummelink, Karlijn, Monkhorst, Kim, Lalezari, Ferry, Lanis, Mara, Rosner, Samuel, Reuss, Joshua E., Smith, Kellie N., Adleff, Vilmos, Rodgers, Kristen, Belcaid, Zineb, Rhymee, Lamia, Levy, Benjamin, Feliciano, Josephine, Hann, Christine L., Ettinger, David S., Georgiades, Christos, Verde, Franco, Illei, Peter, Li, Qing Kay, Baras, Alexander S., Gabrielson, Edward, Brock, Malcolm V., Karchin, Rachel, Pardoll, Drew M., Baylin, Stephen B., Brahmer, Julie R., Scharpf, Robert B., Forde, Patrick M., Velculescu, Victor E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7514475/
https://ncbi.nlm.nih.gov/pubmed/32984843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-019-0008-8
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados