Evolution of neoantigen landscape during immune checkpoint blockade in non-small cell lung cancer

Immune checkpoint inhibitors have shown significant therapeutic responses against tumors containing increased mutation-associated neoantigen load. We have examined the evolving landscape of tumor neoantigens during the emergence of acquired resistance in non-small cell lung cancer patients after ini...

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Udgivet i:Cancer Discov
Main Authors: Anagnostou, Valsamo, Smith, Kellie N., Forde, Patrick M., Niknafs, Noushin, Bhattacharya, Rohit, White, James, Zhang, Theresa, Adleff, Vilmos, Phallen, Jillian, Wali, Neha, Hruban, Carolyn, Guthrie, Violeta B., Rodgers, Kristen, Naidoo, Jarushka, Kang, Hyunseok, Sharfman, William, Georgiades, Christos, Verde, Franco, Illei, Peter, Li, Qing Kay, Gabrielson, Edward, Brock, Malcolm V., Zahnow, Cynthia A., Baylin, Stephen B., Scharpf, Rob, Brahmer, Julie R., Karchin, Rachel, Pardoll, Drew M., Velculescu, Victor E.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733805/
https://ncbi.nlm.nih.gov/pubmed/28031159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0828
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