Evolution of neoantigen landscape during immune checkpoint blockade in non-small cell lung cancer

Immune checkpoint inhibitors have shown significant therapeutic responses against tumors containing increased mutation-associated neoantigen load. We have examined the evolving landscape of tumor neoantigens during the emergence of acquired resistance in non-small cell lung cancer patients after ini...

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Publicat a:Cancer Discov
Autors principals: Anagnostou, Valsamo, Smith, Kellie N., Forde, Patrick M., Niknafs, Noushin, Bhattacharya, Rohit, White, James, Zhang, Theresa, Adleff, Vilmos, Phallen, Jillian, Wali, Neha, Hruban, Carolyn, Guthrie, Violeta B., Rodgers, Kristen, Naidoo, Jarushka, Kang, Hyunseok, Sharfman, William, Georgiades, Christos, Verde, Franco, Illei, Peter, Li, Qing Kay, Gabrielson, Edward, Brock, Malcolm V., Zahnow, Cynthia A., Baylin, Stephen B., Scharpf, Rob, Brahmer, Julie R., Karchin, Rachel, Pardoll, Drew M., Velculescu, Victor E.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733805/
https://ncbi.nlm.nih.gov/pubmed/28031159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0828
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