Dynamics of tumor and immune responses during immune checkpoint blockade in non-small cell lung cancer

Despite the initial successes of immunotherapy, there is an urgent clinical need for molecular assays that identify patients more likely to respond. Here we report that ultrasensitive measures of circulating tumor DNA (ctDNA) and T cell expansion can be used to assess responses to immune checkpoint...

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Bibliografiska uppgifter
I publikationen:Cancer Res
Huvudupphovsmän: Anagnostou, Valsamo, Forde, Patrick M., White, James R., Niknafs, Noushin, Hruban, Carolyn, Naidoo, Jarushka, Marrone, Kristen, Sivakumar, I.K. Ashok, Bruhm, Daniel C., Rosner, Samuel, Phallen, Jillian, Leal, Alessandro, Adleff, Vilmos, Smith, Kellie N., Cottrell, Tricia R., Rhymee, Lamia, Palsgrove, Doreen N., Hann, Christine L., Levy, Benjamin, Feliciano, Josephine, Georgiades, Christos, Verde, Franco, Illei, Peter, Li, Qing Kay, Gabrielson, Edward, Brock, Malcolm V., Isbell, James M., Sauter, Jennifer L., Taube, Janis, Scharpf, Robert B., Karchin, Rachel, Pardoll, Drew M., Chaft, Jamie E., Hellmann, Matthew D., Brahmer, Julie R., Velculescu, Victor E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6432636/
https://ncbi.nlm.nih.gov/pubmed/30541742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-1127
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