Prediction of Drug Exposure in Critically Ill Encephalopathic Neonates Treated With Therapeutic Hypothermia Based on a Pooled Population Pharmacokinetic Analysis of Seven Drugs and Five Metabolites

Drug dosing in encephalopathic neonates treated with therapeutic hypothermia is challenging; exposure is dependent on body size and maturation but can also be influenced by factors related to disease and treatment. A better understanding of underlying pharmacokinetic principles is essential to guide...

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Gepubliceerd in:Clin Pharmacol Ther
Hoofdauteurs: Favié, Laurent M. A., de Haan, Timo R., Bijleveld, Yuma A., Rademaker, Carin M. A., Egberts, Toine C. G., Nuytemans, Debbie H. G. M., Mathôt, Ron A. A., Groenendaal, Floris, Huitema, Alwin D. R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2020
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689752/
https://ncbi.nlm.nih.gov/pubmed/32463940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1917
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