Phenobarbital, Midazolam Pharmacokinetics, Effectiveness, and Drug-Drug Interaction in Asphyxiated Neonates Undergoing Therapeutic Hypothermia

BACKGROUND: Phenobarbital and midazolam are commonly used drugs in (near-)term neonates treated with therapeutic hypothermia for hypoxic-ischaemic encephalopathy, for sedation, and/or as anti-epileptic drug. Phenobarbital is an inducer of cytochrome P450 (CYP) 3A, while midazolam is a CYP3A substrat...

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發表在:Neonatology
Main Authors: Favié, Laurent M.A., Groenendaal, Floris, van den Broek, Marcel P.H., Rademaker, Carin M.A., de Haan, Timo R., van Straaten, Henrica L.M., Dijk, Peter H., van Heijst, Arno, Simons, Sinno H.P., Dijkman, Koen P., Rijken, Monique, Zonnenberg, Inge A., Cools, Filip, Zecic, Alexandra, van der Lee, Johanna H., Nuytemans, Debbie H.G.M., van Bel, Frank, Egberts, Toine C.G., Huitema, Alwin D.R.
格式: Artigo
語言:Inglês
出版: S. Karger AG 2019
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Original Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6878731/
https://ncbi.nlm.nih.gov/pubmed/31256150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000499330
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