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Lidocaine as treatment for neonatal seizures: Evaluation of previously developed population pharmacokinetic models and dosing regimen

AIMS: Lidocaine is used to treat neonatal seizures refractory to other anticonvulsants. It is effective, but also associated with cardiac toxicity. Previous studies have reported on the pharmacokinetics of lidocaine in preterm and term neonates and proposed a dosing regimen for effective and safe li...

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發表在:Br J Clin Pharmacol
Main Authors: Favié, Laurent M.A., Huitema, Alwin D.R., van den Broek, Marcel P.H., Rademaker, Carin M.A., de Haan, Timo R., van Straaten, Henrica L.M., Simons, Sinno H.P., Rijken, Monique, Nuytemans, Debbie H.G.M., Egberts, Toine C.G., Groenendaal, Floris
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983510/
https://ncbi.nlm.nih.gov/pubmed/31663153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14136
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