Lidocaine as treatment for neonatal seizures: Evaluation of previously developed population pharmacokinetic models and dosing regimen

AIMS: Lidocaine is used to treat neonatal seizures refractory to other anticonvulsants. It is effective, but also associated with cardiac toxicity. Previous studies have reported on the pharmacokinetics of lidocaine in preterm and term neonates and proposed a dosing regimen for effective and safe li...

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Foilsithe in:Br J Clin Pharmacol
Main Authors: Favié, Laurent M.A., Huitema, Alwin D.R., van den Broek, Marcel P.H., Rademaker, Carin M.A., de Haan, Timo R., van Straaten, Henrica L.M., Simons, Sinno H.P., Rijken, Monique, Nuytemans, Debbie H.G.M., Egberts, Toine C.G., Groenendaal, Floris
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2020
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Original Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983510/
https://ncbi.nlm.nih.gov/pubmed/31663153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14136
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