Prediction of Drug Exposure in Critically Ill Encephalopathic Neonates Treated With Therapeutic Hypothermia Based on a Pooled Population Pharmacokinetic Analysis of Seven Drugs and Five Metabolites

Drug dosing in encephalopathic neonates treated with therapeutic hypothermia is challenging; exposure is dependent on body size and maturation but can also be influenced by factors related to disease and treatment. A better understanding of underlying pharmacokinetic principles is essential to guide...

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Détails bibliographiques
Publié dans:Clin Pharmacol Ther
Auteurs principaux: Favié, Laurent M. A., de Haan, Timo R., Bijleveld, Yuma A., Rademaker, Carin M. A., Egberts, Toine C. G., Nuytemans, Debbie H. G. M., Mathôt, Ron A. A., Groenendaal, Floris, Huitema, Alwin D. R.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689752/
https://ncbi.nlm.nih.gov/pubmed/32463940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1917
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