Evaluation of a System-Specific Function To Describe the Pharmacokinetics of Benzylpenicillin in Term Neonates Undergoing Moderate Hypothermia

The pharmacokinetic (PK) properties of intravenous (i.v.) benzylpenicillin in term neonates undergoing moderate hypothermia after perinatal asphyxia were evaluated, as they have been unknown until now. A system-specific modeling approach was applied, in which our recently developed covariate model d...

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發表在:Antimicrob Agents Chemother
Main Authors: Bijleveld, Yuma A., de Haan, Timo R., van der Lee, Johanna H., Groenendaal, Floris, Dijk, Peter H., van Heijst, Arno, de Jonge, Rogier C. J., Dijkman, Koen P., van Straaten, Henrica L. M., Rijken, Monique, Zonnenberg, Inge A., Cools, Filip, Zecic, Alexandra, Nuytemans, Debbie H. G. M., van Kaam, Anton H., Mathôt, Ron A. A.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2018
主題:
Pharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5914006/
https://ncbi.nlm.nih.gov/pubmed/29378710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02311-17
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