Evaluation of a System-Specific Function To Describe the Pharmacokinetics of Benzylpenicillin in Term Neonates Undergoing Moderate Hypothermia

The pharmacokinetic (PK) properties of intravenous (i.v.) benzylpenicillin in term neonates undergoing moderate hypothermia after perinatal asphyxia were evaluated, as they have been unknown until now. A system-specific modeling approach was applied, in which our recently developed covariate model d...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Bijleveld, Yuma A., de Haan, Timo R., van der Lee, Johanna H., Groenendaal, Floris, Dijk, Peter H., van Heijst, Arno, de Jonge, Rogier C. J., Dijkman, Koen P., van Straaten, Henrica L. M., Rijken, Monique, Zonnenberg, Inge A., Cools, Filip, Zecic, Alexandra, Nuytemans, Debbie H. G. M., van Kaam, Anton H., Mathôt, Ron A. A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5914006/
https://ncbi.nlm.nih.gov/pubmed/29378710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02311-17
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