Fusion of Bacterial Flagellin to a Dendritic Cell-Targeting αCD40 Antibody Construct Coupled With Viral or Leukemia-Specific Antigens Enhances Dendritic Cell Maturation and Activates Peptide-Responsive T Cells

Conventional dendritic cell (DC) vaccine strategies, in which DCs are loaded with antigens ex vivo, suffer biological issues such as impaired DC migration capacity and laborious GMP production procedures. In a promising alternative, antigens are targeted to DC-associated endocytic receptors in vivo...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Schmitt, Saskia, Tahk, Siret, Lohner, Alina, Hänel, Gerulf, Maiser, Andreas, Hauke, Martina, Patel, Lubna, Rothe, Maurine, Josenhans, Christine, Leonhardt, Heinrich, Griffioen, Marieke, Deiser, Katrin, Fenn, Nadja C., Hopfner, Karl-Peter, Subklewe, Marion
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689061/
https://ncbi.nlm.nih.gov/pubmed/33281829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.602802
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