Fusion of Bacterial Flagellin to a Dendritic Cell-Targeting αCD40 Antibody Construct Coupled With Viral or Leukemia-Specific Antigens Enhances Dendritic Cell Maturation and Activates Peptide-Responsive T Cells

Conventional dendritic cell (DC) vaccine strategies, in which DCs are loaded with antigens ex vivo, suffer biological issues such as impaired DC migration capacity and laborious GMP production procedures. In a promising alternative, antigens are targeted to DC-associated endocytic receptors in vivo...

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Vydáno v:Front Immunol
Hlavní autoři: Schmitt, Saskia, Tahk, Siret, Lohner, Alina, Hänel, Gerulf, Maiser, Andreas, Hauke, Martina, Patel, Lubna, Rothe, Maurine, Josenhans, Christine, Leonhardt, Heinrich, Griffioen, Marieke, Deiser, Katrin, Fenn, Nadja C., Hopfner, Karl-Peter, Subklewe, Marion
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689061/
https://ncbi.nlm.nih.gov/pubmed/33281829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.602802
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