Fusion of Bacterial Flagellin to a Dendritic Cell-Targeting αCD40 Antibody Construct Coupled With Viral or Leukemia-Specific Antigens Enhances Dendritic Cell Maturation and Activates Peptide-Responsive T Cells

Conventional dendritic cell (DC) vaccine strategies, in which DCs are loaded with antigens ex vivo, suffer biological issues such as impaired DC migration capacity and laborious GMP production procedures. In a promising alternative, antigens are targeted to DC-associated endocytic receptors in vivo...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Immunol
Egile Nagusiak: Schmitt, Saskia, Tahk, Siret, Lohner, Alina, Hänel, Gerulf, Maiser, Andreas, Hauke, Martina, Patel, Lubna, Rothe, Maurine, Josenhans, Christine, Leonhardt, Heinrich, Griffioen, Marieke, Deiser, Katrin, Fenn, Nadja C., Hopfner, Karl-Peter, Subklewe, Marion
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2020
Gaiak:
Immunology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689061/
https://ncbi.nlm.nih.gov/pubmed/33281829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.602802
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