SIRPα-antibody fusion proteins stimulate phagocytosis and promote elimination of acute myeloid leukemia cells

CD47, expressed on a variety of tumor cells, confers immune resistance by delivering an inhibitory “don't eat me” signal to phagocytic cells via its myeloid-specific receptor SIRPα. Recent studies have shown that blocking the CD47-SIRPα axis with CD47-directed antibodies or antibody-derivatives...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ponce, Laia Pascual, Fenn, Nadja C., Moritz, Nadine, Krupka, Christina, Kozik, Jan-Hendrik, Lauber, Kirsten, Subklewe, Marion, Hopfner, Karl-Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355265/
https://ncbi.nlm.nih.gov/pubmed/28061465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14500
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