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SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells

Prnp(−/−) mice lack the prion protein PrP(C) and are resistant to prion infections, but variable phenotypes have been reported in Prnp(−/−) mice and the physiological function of PrP(C) remains poorly understood. Here we examined a cell-autonomous phenotype, inhibition of macrophage phagocytosis of...

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Detalhes bibliográficos
Main Authors: Nuvolone, Mario, Kana, Veronika, Hutter, Gregor, Sakata, Daiji, Mortin-Toth, Steven M., Russo, Giancarlo, Danska, Jayne S., Aguzzi, Adriano
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832919/
https://ncbi.nlm.nih.gov/pubmed/24145514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131274
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