Fusion of Bacterial Flagellin to a Dendritic Cell-Targeting αCD40 Antibody Construct Coupled With Viral or Leukemia-Specific Antigens Enhances Dendritic Cell Maturation and Activates Peptide-Responsive T Cells

Conventional dendritic cell (DC) vaccine strategies, in which DCs are loaded with antigens ex vivo, suffer biological issues such as impaired DC migration capacity and laborious GMP production procedures. In a promising alternative, antigens are targeted to DC-associated endocytic receptors in vivo...

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Main Authors: Saskia Schmitt, Siret Tahk, Alina Lohner, Gerulf Hänel, Andreas Maiser, Martina Hauke, Lubna Patel, Maurine Rothe, Christine Josenhans, Heinrich Leonhardt, Marieke Griffioen, Katrin Deiser, Nadja C. Fenn, Karl-Peter Hopfner, Marion Subklewe
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-11-01
Colecção:Frontiers in Immunology
Assuntos:
dendritic cell
flagellin
neoantigen
vaccine
antibody
acute myeloid leukemia
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2020.602802/full
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