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Preclinical and clinical development of therapeutic antibodies targeting functions of CD47 in the tumor microenvironment
CD47 is a ubiquitously expressed cell surface glycoprotein that functions as a signaling receptor for thrombospondin-1 and as the counter-receptor for signal regulatory protein-α (SIRPα). Engaging SIRPα on macrophages inhibits phagocytosis, and CD47 thereby serves as a physiological marker of self....
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| Udgivet i: | Antib Ther |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7687918/ https://ncbi.nlm.nih.gov/pubmed/33244513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/abt/tbaa017 |
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