Preclinical development of a bispecific antibody that safely and effectively targets CD19 and CD47 for the treatment of B cell lymphoma and leukemia

CD47, a ubiquitously expressed innate immune checkpoint receptor that serves as a universal “don’t eat me” signal of phagocytosis, is often up-regulated by hematological and solid cancers to evade immune surveillance. Development of CD47-targeted modalities is hindered by the ubiquitous expression o...

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Vydáno v:Mol Cancer Ther
Hlavní autoři: Buatois, Vanessa, Johnson, Zoë, Pires, Susana Salgado, Papaioannou, Anne, Hatterer, Eric, Chauchet, Xavier, Richard, Françoise, Barba, Leticia, Daubeuf, Bruno, Cons, Laura, Broyer, Lucile, D’Asaro, Matilde, Matthes, Thomas, LeGallou, Simon, Fest, Thierry, Tarte, Karin, Hinojosa, Robert K. Clarke, Ferrer, Eulàlia Genescà, Ribera, José María, Dey, Aditi, Bailey, Katharine, Fielding, Adele K., Eissenberg, Linda, Ritchey, Julie, Rettig, Michael, DiPersio, John F., Kosco-Vilbois, Marie H., Masternak, Krzysztof, Fischer, Nicolas, Shang, Limin, Ferlin, Walter G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072583/
https://ncbi.nlm.nih.gov/pubmed/29743205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-1095
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