Co-engaging CD47 and CD19 with a bispecific antibody abrogates B-cell receptor/CD19 association leading to impaired B-cell proliferation

CD19 is a B cell-specific receptor that regulates the threshold of B cell receptor (BCR)-mediated cell proliferation. A CD47xCD19 bispecific antibody (biAb) was generated to target and deplete B cells via multiple antibody-mediated mechanisms. Interestingly, the biAb, constructed of a CD19 binding a...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:MAbs
Huvudupphovsmän: Hatterer, Eric, Barba, Leticia, Noraz, Nelly, Daubeuf, Bruno, Aubry-Lachainaye, Jean-Pierre, von der Weid, Benoit, Richard, Françoise, Kosco-Vilbois, Marie, Ferlin, Walter, Shang, Limin, Buatois, Vanessa
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2019
Ämnen:
Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380423/
https://ncbi.nlm.nih.gov/pubmed/30569825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1558698
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk