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Preclinical and clinical development of therapeutic antibodies targeting functions of CD47 in the tumor microenvironment
CD47 is a ubiquitously expressed cell surface glycoprotein that functions as a signaling receptor for thrombospondin-1 and as the counter-receptor for signal regulatory protein-α (SIRPα). Engaging SIRPα on macrophages inhibits phagocytosis, and CD47 thereby serves as a physiological marker of self....
Sparad:
| I publikationen: | Antib Ther |
|---|---|
| Huvudupphovsmän: | , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Oxford University Press
2020
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7687918/ https://ncbi.nlm.nih.gov/pubmed/33244513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/abt/tbaa017 |
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