Enhancing therapeutic efficacy of in vivo platelet-targeted gene therapy in hemophilia A mice

Our previous studies demonstrated that intraosseous (IO) infusion of lentiviral vectors (LVs) carrying a modified B domain–deleted factor VIII (FVIII) transgene driven by a megakaryocyte-specific promoter (GP1Bα promoter; G-F8/N6-LV) successfully transduced hematopoietic stem cells (HSCs) to produce...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Blood Adv
Glavni autori: Wang, Xuefeng, Fu, Richard Y., Li, Chong, Chen, Chun-Yu, Firrman, Jenni, Konkle, Barbara A., Zhang, Junping, Li, Lei, Xiao, Weidong, Poncz, Mortimer, Miao, Carol H.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2020
Teme:
Thrombosis and Hemostasis
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686911/
https://ncbi.nlm.nih.gov/pubmed/33216891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002479
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items