Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit

Activation of the Hedgehog pathway may have therapeutic value for improved bone healing, taste receptor cell regeneration, and alleviation of colitis or other conditions. Systemic pathway activation, however, may be detrimental, and agents amenable to tissue targeting for therapeutic application hav...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Zhang, Yunxiao, Lu, Wan-Jin, Bulkley, David P., Liang, Jiahao, Ralko, Arthur, Han, Shuo, Roberts, Kelsey J., Li, Anping, Cho, Wonhwa, Cheng, Yifan, Manglik, Aashish, Beachy, Philip A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682405/
https://ncbi.nlm.nih.gov/pubmed/33139559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011560117
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