Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit

Activation of the Hedgehog pathway may have therapeutic value for improved bone healing, taste receptor cell regeneration, and alleviation of colitis or other conditions. Systemic pathway activation, however, may be detrimental, and agents amenable to tissue targeting for therapeutic application hav...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhang, Yunxiao, Lu, Wan-Jin, Bulkley, David P., Liang, Jiahao, Ralko, Arthur, Han, Shuo, Roberts, Kelsey J., Li, Anping, Cho, Wonhwa, Cheng, Yifan, Manglik, Aashish, Beachy, Philip A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682405/
https://ncbi.nlm.nih.gov/pubmed/33139559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011560117
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