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Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit
Activation of the Hedgehog pathway may have therapeutic value for improved bone healing, taste receptor cell regeneration, and alleviation of colitis or other conditions. Systemic pathway activation, however, may be detrimental, and agents amenable to tissue targeting for therapeutic application hav...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7682405/ https://ncbi.nlm.nih.gov/pubmed/33139559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011560117 |
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