Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit

Activation of the Hedgehog pathway may have therapeutic value for improved bone healing, taste receptor cell regeneration, and alleviation of colitis or other conditions. Systemic pathway activation, however, may be detrimental, and agents amenable to tissue targeting for therapeutic application hav...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Zhang, Yunxiao, Lu, Wan-Jin, Bulkley, David P., Liang, Jiahao, Ralko, Arthur, Han, Shuo, Roberts, Kelsey J., Li, Anping, Cho, Wonhwa, Cheng, Yifan, Manglik, Aashish, Beachy, Philip A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682405/
https://ncbi.nlm.nih.gov/pubmed/33139559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011560117
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