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Smoothened stimulation by membrane sterols drives Hedgehog pathway activity

Hedgehog signalling is fundamental to embryonic development and postnatal tissue regeneration(1). Aberrant postnatal Hedgehog signalling leads to several malignancies, including basal cell carcinoma and paediatric medulloblastoma(2). Hedgehog proteins bind to and inhibit the transmembrane cholestero...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Deshpande, Ishan, Liang, Jiahao, Hedeen, Danielle, Roberts, Kelsey J., Zhang, Yunxiao, Ha, Betty, Latorraca, Naomi R., Faust, Bryan, Dror, Ron O., Beachy, Philip A., Myers, Benjamin R., Manglik, Aashish
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709672/
https://ncbi.nlm.nih.gov/pubmed/31263273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1355-4
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