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Smoothened stimulation by membrane sterols drives Hedgehog pathway activity
Hedgehog signalling is fundamental to embryonic development and postnatal tissue regeneration(1). Aberrant postnatal Hedgehog signalling leads to several malignancies, including basal cell carcinoma and paediatric medulloblastoma(2). Hedgehog proteins bind to and inhibit the transmembrane cholestero...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6709672/ https://ncbi.nlm.nih.gov/pubmed/31263273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1355-4 |
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