Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits

The Hedgehog (Hh) pathway is essential for organ development, homeostasis, and regeneration. Dysfunction of this cascade drives several cancers. To control expression of pathway target genes, the G protein–coupled receptor (GPCR) Smoothened (SMO) activates glioma-associated (GLI) transcription facto...

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Détails bibliographiques
Publié dans:PLoS Biol
Auteurs principaux: Arveseth, Corvin D., Happ, John T., Hedeen, Danielle S., Zhu, Ju-Fen, Capener, Jacob L., Klatt Shaw, Dana, Deshpande, Ishan, Liang, Jiahao, Xu, Jiewei, Stubben, Sara L., Nelson, Isaac B., Walker, Madison F., Kawakami, Kouki, Inoue, Asuka, Krogan, Nevan J., Grunwald, David J., Hüttenhain, Ruth, Manglik, Aashish, Myers, Benjamin R.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2021
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8096101/
https://ncbi.nlm.nih.gov/pubmed/33886552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3001191
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