Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits

The Hedgehog (Hh) pathway is essential for organ development, homeostasis, and regeneration. Dysfunction of this cascade drives several cancers. To control expression of pathway target genes, the G protein–coupled receptor (GPCR) Smoothened (SMO) activates glioma-associated (GLI) transcription facto...

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Publicat a:PLoS Biol
Autors principals: Arveseth, Corvin D., Happ, John T., Hedeen, Danielle S., Zhu, Ju-Fen, Capener, Jacob L., Klatt Shaw, Dana, Deshpande, Ishan, Liang, Jiahao, Xu, Jiewei, Stubben, Sara L., Nelson, Isaac B., Walker, Madison F., Kawakami, Kouki, Inoue, Asuka, Krogan, Nevan J., Grunwald, David J., Hüttenhain, Ruth, Manglik, Aashish, Myers, Benjamin R.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8096101/
https://ncbi.nlm.nih.gov/pubmed/33886552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3001191
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