Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits

The Hedgehog (Hh) pathway is essential for organ development, homeostasis, and regeneration. Dysfunction of this cascade drives several cancers. To control expression of pathway target genes, the G protein–coupled receptor (GPCR) Smoothened (SMO) activates glioma-associated (GLI) transcription facto...

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書誌詳細
出版年:PLoS Biol
主要な著者: Arveseth, Corvin D., Happ, John T., Hedeen, Danielle S., Zhu, Ju-Fen, Capener, Jacob L., Klatt Shaw, Dana, Deshpande, Ishan, Liang, Jiahao, Xu, Jiewei, Stubben, Sara L., Nelson, Isaac B., Walker, Madison F., Kawakami, Kouki, Inoue, Asuka, Krogan, Nevan J., Grunwald, David J., Hüttenhain, Ruth, Manglik, Aashish, Myers, Benjamin R.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2021
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8096101/
https://ncbi.nlm.nih.gov/pubmed/33886552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3001191
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