Smoothened stimulation by membrane sterols drives Hedgehog pathway activity

Hedgehog signalling is fundamental to embryonic development and postnatal tissue regeneration(1). Aberrant postnatal Hedgehog signalling leads to several malignancies, including basal cell carcinoma and paediatric medulloblastoma(2). Hedgehog proteins bind to and inhibit the transmembrane cholestero...

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Pubblicato in:Nature
Autori principali: Deshpande, Ishan, Liang, Jiahao, Hedeen, Danielle, Roberts, Kelsey J., Zhang, Yunxiao, Ha, Betty, Latorraca, Naomi R., Faust, Bryan, Dror, Ron O., Beachy, Philip A., Myers, Benjamin R., Manglik, Aashish
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709672/
https://ncbi.nlm.nih.gov/pubmed/31263273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1355-4
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