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Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit
Activation of the Hedgehog pathway may have therapeutic value for improved bone healing, taste receptor cell regeneration, and alleviation of colitis or other conditions. Systemic pathway activation, however, may be detrimental, and agents amenable to tissue targeting for therapeutic application hav...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2020
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7682405/ https://ncbi.nlm.nih.gov/pubmed/33139559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011560117 |
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