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Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit

Activation of the Hedgehog pathway may have therapeutic value for improved bone healing, taste receptor cell regeneration, and alleviation of colitis or other conditions. Systemic pathway activation, however, may be detrimental, and agents amenable to tissue targeting for therapeutic application hav...

詳細記述

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Zhang, Yunxiao, Lu, Wan-Jin, Bulkley, David P., Liang, Jiahao, Ralko, Arthur, Han, Shuo, Roberts, Kelsey J., Li, Anping, Cho, Wonhwa, Cheng, Yifan, Manglik, Aashish, Beachy, Philip A.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682405/
https://ncbi.nlm.nih.gov/pubmed/33139559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011560117
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