Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched

Hedgehog protein signals mediate tissue patterning and maintenance via binding to and inactivation of their common receptor Patched, a twelve-transmembrane protein that otherwise would suppress activity of the seven-transmembrane protein, Smoothened. Loss of Patched function, the most common cause o...

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Publicado no:Cell
Main Authors: Zhang, Yunxiao, Bulkley, David P., Xin, Yao, Roberts, Kelsey J., Asarnow, Daniel E., Sharma, Ashutosh, Myers, Benjamin R., Cho, Wonhwa, Cheng, Yifan, Beachy, Philip A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326742/
https://ncbi.nlm.nih.gov/pubmed/30415841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.10.026
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