Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinylethyl-aminopiperidines and -piperidine amines at the Dopamine Transporter: Bioisosteric Replacement of the Piperazine Improves Metabolic Stability

Despite considerable efforts to develop medications to treat psychostimulant use disorders, none have proven effective, leaving an underserved patient population and unanswered questions as to what mechanism(s) of action should be targeted for developing pharmacotherapies. Atypical dopamine transpor...

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Bibliografiske detaljer
Udgivet i:Eur J Med Chem
Main Authors: Giancola, JoLynn B., Bonifazi, Alessandro, Cao, Jianjing, Ku, Therese, Haraczy, Alexandra J., Lam, Jenny, Rais, Rana, Coggiano, Mark A., Tanda, Gianluigi, Newman, Amy Hauck
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680422/
https://ncbi.nlm.nih.gov/pubmed/32947229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112674
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