Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters

[Image: see text] Missense mutations that give rise to protein misfolding are rare, but collectively, defective protein folding diseases are consequential. Folding deficiencies are amenable to pharmacological correction (pharmacochaperoning), but the underlying mechanisms remain enigmatic. Ibogaine...

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Bibliografske podrobnosti
izdano v:ACS Pharmacol Transl Sci
Main Authors: Bhat, Shreyas, Guthrie, Daryl A., Kasture, Ameya, El-Kasaby, Ali, Cao, Jianjing, Bonifazi, Alessandro, Ku, Therese, Giancola, JoLynn B., Hummel, Thomas, Freissmuth, Michael, Newman, Amy Hauck
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2020
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8033614/
https://ncbi.nlm.nih.gov/pubmed/33860180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00102
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