Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters

[Image: see text] Missense mutations that give rise to protein misfolding are rare, but collectively, defective protein folding diseases are consequential. Folding deficiencies are amenable to pharmacological correction (pharmacochaperoning), but the underlying mechanisms remain enigmatic. Ibogaine...

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Détails bibliographiques
Publié dans:ACS Pharmacol Transl Sci
Auteurs principaux: Bhat, Shreyas, Guthrie, Daryl A., Kasture, Ameya, El-Kasaby, Ali, Cao, Jianjing, Bonifazi, Alessandro, Ku, Therese, Giancola, JoLynn B., Hummel, Thomas, Freissmuth, Michael, Newman, Amy Hauck
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2020
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8033614/
https://ncbi.nlm.nih.gov/pubmed/33860180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00102
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