Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates

Point mutations in SLC6 transporters cause misfolding, which can be remedied by pharmacochaperones. The serotonin transporter (SERT/SLC6A4) has a rich pharmacology including inhibitors, releasers (amphetamines, which promote the exchange mode), and more recently, discovered partial substrates. We hy...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Bhat, Shreyas, Hasenhuetl, Peter S., Kasture, Ameya, El-Kasaby, Ali, Baumann, Michael H., Blough, Bruce E., Sucic, Sonja, Sandtner, Walter, Freissmuth, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633137/
https://ncbi.nlm.nih.gov/pubmed/28842491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.794081
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados