Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates

Point mutations in SLC6 transporters cause misfolding, which can be remedied by pharmacochaperones. The serotonin transporter (SERT/SLC6A4) has a rich pharmacology including inhibitors, releasers (amphetamines, which promote the exchange mode), and more recently, discovered partial substrates. We hy...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Bhat, Shreyas, Hasenhuetl, Peter S., Kasture, Ameya, El-Kasaby, Ali, Baumann, Michael H., Blough, Bruce E., Sucic, Sonja, Sandtner, Walter, Freissmuth, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2017
Soggetti:
Neurobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633137/
https://ncbi.nlm.nih.gov/pubmed/28842491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.794081
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