Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates

Point mutations in SLC6 transporters cause misfolding, which can be remedied by pharmacochaperones. The serotonin transporter (SERT/SLC6A4) has a rich pharmacology including inhibitors, releasers (amphetamines, which promote the exchange mode), and more recently, discovered partial substrates. We hy...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Bhat, Shreyas, Hasenhuetl, Peter S., Kasture, Ameya, El-Kasaby, Ali, Baumann, Michael H., Blough, Bruce E., Sucic, Sonja, Sandtner, Walter, Freissmuth, Michael
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633137/
https://ncbi.nlm.nih.gov/pubmed/28842491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.794081
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