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Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates
Point mutations in SLC6 transporters cause misfolding, which can be remedied by pharmacochaperones. The serotonin transporter (SERT/SLC6A4) has a rich pharmacology including inhibitors, releasers (amphetamines, which promote the exchange mode), and more recently, discovered partial substrates. We hy...
Zapisane w:
| Wydane w: | J Biol Chem |
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| Główni autorzy: | , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Biochemistry and Molecular Biology
2017
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5633137/ https://ncbi.nlm.nih.gov/pubmed/28842491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.794081 |
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