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Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinylethyl-aminopiperidines and -piperidine amines at the Dopamine Transporter: Bioisosteric Replacement of the Piperazine Improves Metabolic Stability

Despite considerable efforts to develop medications to treat psychostimulant use disorders, none have proven effective, leaving an underserved patient population and unanswered questions as to what mechanism(s) of action should be targeted for developing pharmacotherapies. Atypical dopamine transpor...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Giancola, JoLynn B., Bonifazi, Alessandro, Cao, Jianjing, Ku, Therese, Haraczy, Alexandra J., Lam, Jenny, Rais, Rana, Coggiano, Mark A., Tanda, Gianluigi, Newman, Amy Hauck
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680422/
https://ncbi.nlm.nih.gov/pubmed/32947229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112674
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