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Mechanistic Studies of the Multiple Myeloma and Melanoma Cell-Selective Toxicity of the Rpn13-Binding Peptoid KDT-11

We previously reported a peptoid ligand for the proteasomal ubiquitin receptor Rpn13 called KDT-11 and demonstrated that this compound is toxic to multiple myeloma (MM) cells, but not non-malignant cells. We show here that KDT-11 decreases the viability of a variety of cancer cell lines, especially...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Dickson, Paige, Simanski, Scott, Ngundu, John Maina, Kodadek, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680388/
https://ncbi.nlm.nih.gov/pubmed/32857986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.08.008
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