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A Reversible and Highly Selective Inhibitor of the Proteasomal Ubiquitin Receptor Rpn13 Is Toxic To Multiple Myeloma Cells
The proteasome is a multi-subunit complex responsible for most non-lysosomal turnover of proteins in eukaryotic cells. Proteasome inhibitors are of great interest clinically, particularly for the treatment of multiple myeloma (MM). Unfortunately, resistance arises almost inevitably to these active s...
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| Pubblicato in: | J Am Chem Soc |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4455945/ https://ncbi.nlm.nih.gov/pubmed/25914958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b02069 |
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