Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets

Proteasome–ubiquitin receptor hRpn13/Adrm1 binds and activates deubiquitinating enzyme Uch37/UCHL5 and is targeted by bis-benzylidine piperidone RA190, which restricts cancer growth in mice xenografts. Here, we solve the structure of hRpn13 with a segment of hRpn2 that serves as its proteasome docki...

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Publié dans:Nat Commun
Auteurs principaux: Lu, Xiuxiu, Nowicka, Urszula, Sridharan, Vinidhra, Liu, Fen, Randles, Leah, Hymel, David, Dyba, Marzena, Tarasov, Sergey G., Tarasova, Nadya I., Zhao, Xue Zhi, Hamazaki, Jun, Murata, Shigeo, Burke, Jr., Terrence R., Walters, Kylie J.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5494190/
https://ncbi.nlm.nih.gov/pubmed/28598414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15540
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