Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190

Rpn13 is one of several ubiquitin receptors in the 26S proteasome. Cys88 of Rpn13 has been proposed to be the principal target of RA190, an electrophilic small molecule with interesting anti-cancer activities. Here, we examine the claim that RA190 mediates its cytotoxic effects through engagement wi...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Dickson, Paige, Abegg, Daniel, Vinogradova, Ekaterina, Takaya, Junichiro, An, Hongchan, Simanski, Scott, Cravatt, Benjamin F., Adibekian, Alexander, Kodadek, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680414/
https://ncbi.nlm.nih.gov/pubmed/32857985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.08.007
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