Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion

Fluoxazolevir is an aryloxazole-based entry inhibitor of hepatitis C virus (HCV). We show that fluoxazolevir inhibits fusion of HCV with hepatic cells by binding HCV envelope protein 1 (E1) to prevent fusion. 9 of 10 fluoxazolevir-resistance-associated substitutions are in the E1 protein and 4 are i...

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Publicado no:Nat Microbiol
Main Authors: Ma, Christopher D., Imamura, Michio, Talley, Daniel C., Rolt, Adam, Xu, Xin, Wang, Amy Q., Le, Derek, Uchida, Takuro, Osawa, Mitsutaka, Teraoka, Yuji, Li, Kelin, Hu, Xin, Park, Seung Bum, Chalasani, Nishanth, Irvin, Parker H., Dulcey, Andres E., Southall, Noel, Marugan, Juan J., Hu, Zongyi, Chayama, Kazuaki, Frankowski, Kevin J., Liang, T. Jake
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7677215/
https://ncbi.nlm.nih.gov/pubmed/32868923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-020-0781-2
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